The Best Hybrid Cannabis Strains

What is a hybrid strain?

Hybrid weed strains are just what the name suggests. That is, a mixture of Indica and Sativa genetics and characteristics. This type of naming system is starting to become somewhat outdated, as newer research is showing that it is the terpene and cannabinoid profiles that determine the actual effect of a given strain, but it is still a useful way to classify weed strains.

Hybrid strains offer unique combinations of effects and flavors, and run the gamut from heavily Sativa-based to more Indica-dominant, with many trying to strike that balance of a perfect 50/50 blend. There are actually very few strains left in the modern weed world that are pure Indica or pure Sativa, as most of the strains grown today are a hybrid of the two.

Think of hybrids as the best of both worlds, combining Sativa's energizing and creative effects with the relaxing and pain-relieving properties of Indica. They can be great for users who want a more balanced high without feeling too sleepy or overly hyped.

What are the benefits of hybrid strains?

Unlike the more pure Sativa or Indica options out there, hybrid cultivars offer a variety of potential benefits from both sides of the cannabis genetic split. 

Some strains may focus more on the Sativa side, giving users an energetic and uplifting high that can boost creativity and productivity. The more Indica-dominant strains, on the other hand, will usually provide a more calming and sedating effect, perfect for relaxing after a long day or helping those dealing with pain and anxiety.

But, perhaps the greatest benefit of hybrid strains is their versatility. With such a wide range of effects and flavors, there really is something for everyone. In this modern age of cannabis legality, it wouldn't be an overstatement to say that hybrid strains are the backbone of the industry, and it would take literal months to look over every option properly.

MSNL’s top-rated hybrid strains

To make life easy, below, we have cut away the chaff and whittled the competition down to our 11 absolute best hybrids. There's something for everyone here, from balanced bangers to heavy-duty THC beasts.

Gorilla Glue

Gorilla Glue is up there with the most famous strains of all time, and definitely one of the best new school hybrids around. GG burst onto the scene and scooped a ton of awards, including Best Hybrid at the 2014 Cannabis Cup with a whopping 32% THC. The combo of electrifyingly potent effect, tasty-as-hell flavor, and rock-solid growing credentials really does put the icing on the cake.

With notes of pine, and chocolate hiding under a diesel punch, Gorilla Glue can produce a heady high that leaves users both relaxed and uplifted. It's known for its ability to help with chronic pain and stress relief, making it a popular choice among medical marijuana patients.

Bruce Banner (Sativa Dominant Hybrid)

This hulk of a strain comes to the table with around 80% Sativa genetics, looking to pound down its Indica opponents with a whopping 28% THC count. And hit hard it does, but maybe not how you would expect. The high is definitely more of a creeper, building up over 20 or so minutes, but with almost zero couchlock. Bruce Banner offers a wonderful one-two combo of energizing euphoria and physical relaxation.

Wedding Cake (Leafly Strain of the Year 2019)

Wedding Cake is one of those rare offerings that pretty much has everything going for it. It's good-looking, tasty, potent, and up there with the easiest-to-grow top-shelf strains of all time. A strong yet not eye-watering 24% THC is backed up with some sky-high terpene levels, including a whopping 3% Myrcene!

The high is relaxing without being overly sedating, and the flavor profile lives up to its name, with a tangy sourness and fruity undertones. This one is definitely a contender for the best hybrid strain out there, even 5 years after being awarded the converted Leafly 'Strain of the Year' for 2019.

Runtz (Leafly Strain of the Year 2020)

Speaking of Leafly Strains of the Year awards, Runtz took home the prize in 2020 with its insanely candy-like flavor and balanced high. With around 24% THC, it's not going to break any records, and while we all love a heavyweight, potency just isn't the be-all and end-all.

This strain is all about big, tasty, dessert-like flavors that keep you coming back for more. The high is a perfect blend of cerebral energy and body relaxation, making it ideal for both social situations and just chilling at home. Another one on the beginner growing list, and boy, can she handle some nutes!

THC Bomb (Indica Dominant)

With over 15 years of continued popularity and multiple awards under its belt, THC Bomb is a classic hybrid strain that has stood the test of time. It's a perfectly balanced hybrid strain with plus 25% THC, making it perfect for those looking for strong physical effects and pain relief without being glued to the couch.

There is an almost 100% chance that even if you haven't grown THC bomb, you've already smoked it. One of the most popular commercial strains of all time thanks to its ridiculous yield potential, banging terpene profile, and how forgiving she is to cultivate.

Godfather OG (Most Potent Hybrid)

If you're chasing a strain that is sure to blow your socks off, then Godfather OG has to be in the running. This super stable cultivar consistently pushes out over 30% THC without breaking a sweat and is capable of tipping the 35% THC barrier. No wonder she took home Best Indica at High Times Cannabis Cup 2013.

But it's not all about the numbers with this strain. She has a complex and delicious flavor profile, with hints of grapefruit, lemon, and a woody base - a combo not often seen in newer strains, but one that needs bringing back!

Harle-Tsu (Best Medical Hybrid)

Harle-Tsu has been a godsend for many, thanks to this strain's ability to pump out more than 24% CBD, making it one of the most sought-after medical strains on the planet. This is mixed with a light smattering of THC, not enough to get you high necessarily, but definitely enough to get the "entourage effect" going.

CBD-dominant hybrids are sometimes a little flavorless, but Harle-Tsu brings a dank citrusy, spicy vibe to the table that is complimented by a tasty earthiness. It's also an easy one to grow, making it perfect for those looking for a little help with their ailments without having to dive into hardcore growing techniques.

Gorilla Zkittlez Auto

What do you get when you cross Gorilla Glue and Zkittlez and then slip a little Ruderalis genetics in?

Gorilla Zkittlez Auto, and it's every bit the hybrid you would expect, with a slight Indica dominance and the added bonus of just 8 to 10 weeks from seed to harvest!

One of the last strains on this list, and the only autoflowering option, but still every bit as much deserving of its spot. The delicious blend of fruity and earthy flavors, combined with a balanced high that leans more to the Indica side of the scale, makes this sedating option a must-try for all budding growers out there.

Purple Haze

No "Best Hybrid" list would be complete without a classic strain that has stood the test of time and influenced generations. Purple Haze is one of those strains that literally everyone knows, whether they enjoy the occasional smoke or not.

This strain is a Sativa-dominant hybrid, with just enough Indica genetics to keep the more anxious among us at ease. The high is uplifting and energetic, perfect for a night out watching a live band or just generally getting things done. The flavor profile is iconic, with earthy and fruity notes giving way to a spicy finish, and the buds come with about as much bag appeal as we have ever seen!

Do hybrid strains get you more high?

Not necessarily. The potency of a strain is determined by its THC and CBD levels, which can vary greatly depending on the genetics and growing conditions. Hybrid strains can have varying levels of these cannabinoids, just like any other strain. However, some hybrid strains may produce a more well-rounded high due to their balanced blend of both Indica and Sativa genetics.

How are hybridised strains created?

Hybrid strains are created through a process of crossbreeding different cannabis strains. This involves intentionally pollinating one a female plant with the pollen from another male strain, resulting in offspring that possess qualities from both parent plants. The resulting cultivars are then selectively bred to enhance certain desired traits and create a new hybrid strain with unique characteristics.

It can take several generations of back-breeding and selection to get to a stable, consistent hybrid strain. This process requires a great deal of knowledge and skill, as well as time and patience. But when done successfully, as seen with the top hybrid strains listed here, the result is a unique and potent strain that offers a well-rounded experience for cannaheads!

What is the strongest hybrid strain?

Right now, Godfather OG claims the crown of the strongest hybrid strain, with its potential to produce over 35% THC. However, this can vary depending on growing conditions and genetics. Other heavily potent hybrid strains include Gorilla Glue #4, Girl Scout Cookies, and Bruce Banner.